Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice
Identifieur interne : 000886 ( Main/Exploration ); précédent : 000885; suivant : 000887Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice
Auteurs : Mieko Muramatsu [Japon] ; Reiko Yoshida [Japon] ; Hiroko Miyamoto [Japon] ; Daisuke Tomabechi [Japon] ; Masahiro Kajihara [Japon] ; Junki Maruyama [Japon] ; Takashi Kimura [Japon] ; Rashid Manzoor [Japon] ; Kimihito Ito [Japon] ; Ayato Takada [Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Influenza A virus subtypes are classified on the basis of the antigenicity of their envelope glycoproteins, hemagglutinin (HA; H1–H17) and neuraminidase. Since HA-specific neutralizing antibodies are predominantly specific for a single HA subtype, the contribution of antibodies to the heterosubtypic immunity is not fully understood. In this study, mice were immunized intranasally or subcutaneously with viruses having the H1, H3, H5, H7, H9, or H13 HA subtype, and cross-reactivities of induced IgG and IgA antibodies to recombinant HAs of the H1–H16 subtypes were analyzed. We found that both subcutaneous and intranasal immunizations induced antibody responses to multiple HAs of different subtypes, whereas IgA was not detected remarkably in mice immunized subcutaneously. Using serum, nasal wash, and trachea-lung wash samples of H9 virus-immunized mice, neutralizing activities of cross-reactive antibodies were then evaluated by plaque-reduction assays. As expected, no heterosubtypic neutralizing activity was detected by a standard neutralization test in which viruses were mixed with antibodies prior to inoculation into cultured cells. Interestingly, however, a remarkable reduction of plaque formation and extracellular release of the H12 virus, which was bound by the H9-induced cross-reactive antibodies, was observed when infected cells were subsequently cultured with the samples containing HA-specific cross-reactive IgA. This heterosubtypic plaque reduction was interfered when the samples were pretreated with anti-mouse IgA polyclonal serum. These results suggest that the majority of HA-specific cross-reactive IgG and IgA antibodies produced by immunization do not block cellular entry of viruses, but cross-reactive IgA may have the potential to inhibit viral egress from infected cells and thus to play a role in heterosubtypic immunity against influenza A viruses.
Url:
DOI: 10.1371/journal.pone.0071534
PubMed: 23977065
PubMed Central: 3745432
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B66
- to stream Pmc, to step Curation: 000B66
- to stream Pmc, to step Checkpoint: 000620
- to stream Ncbi, to step Merge: 000944
- to stream Ncbi, to step Curation: 000944
- to stream Ncbi, to step Checkpoint: 000944
- to stream Main, to step Merge: 000887
- to stream Main, to step Curation: 000886
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice</title>
<author><name sortKey="Muramatsu, Mieko" sort="Muramatsu, Mieko" uniqKey="Muramatsu M" first="Mieko" last="Muramatsu">Mieko Muramatsu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshida, Reiko" sort="Yoshida, Reiko" uniqKey="Yoshida R" first="Reiko" last="Yoshida">Reiko Yoshida</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miyamoto, Hiroko" sort="Miyamoto, Hiroko" uniqKey="Miyamoto H" first="Hiroko" last="Miyamoto">Hiroko Miyamoto</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomabechi, Daisuke" sort="Tomabechi, Daisuke" uniqKey="Tomabechi D" first="Daisuke" last="Tomabechi">Daisuke Tomabechi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kajihara, Masahiro" sort="Kajihara, Masahiro" uniqKey="Kajihara M" first="Masahiro" last="Kajihara">Masahiro Kajihara</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maruyama, Junki" sort="Maruyama, Junki" uniqKey="Maruyama J" first="Junki" last="Maruyama">Junki Maruyama</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kimura, Takashi" sort="Kimura, Takashi" uniqKey="Kimura T" first="Takashi" last="Kimura">Takashi Kimura</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manzoor, Rashid" sort="Manzoor, Rashid" uniqKey="Manzoor R" first="Rashid" last="Manzoor">Rashid Manzoor</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ito, Kimihito" sort="Ito, Kimihito" uniqKey="Ito K" first="Kimihito" last="Ito">Kimihito Ito</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Division of Bioinformatics, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Bioinformatics, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takada, Ayato" sort="Takada, Ayato" uniqKey="Takada A" first="Ayato" last="Takada">Ayato Takada</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23977065</idno>
<idno type="pmc">3745432</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745432</idno>
<idno type="RBID">PMC:3745432</idno>
<idno type="doi">10.1371/journal.pone.0071534</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000B66</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B66</idno>
<idno type="wicri:Area/Pmc/Curation">000B66</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B66</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000620</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000620</idno>
<idno type="wicri:Area/Ncbi/Merge">000944</idno>
<idno type="wicri:Area/Ncbi/Curation">000944</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000944</idno>
<idno type="wicri:Area/Main/Merge">000887</idno>
<idno type="wicri:Area/Main/Curation">000886</idno>
<idno type="wicri:Area/Main/Exploration">000886</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice</title>
<author><name sortKey="Muramatsu, Mieko" sort="Muramatsu, Mieko" uniqKey="Muramatsu M" first="Mieko" last="Muramatsu">Mieko Muramatsu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoshida, Reiko" sort="Yoshida, Reiko" uniqKey="Yoshida R" first="Reiko" last="Yoshida">Reiko Yoshida</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miyamoto, Hiroko" sort="Miyamoto, Hiroko" uniqKey="Miyamoto H" first="Hiroko" last="Miyamoto">Hiroko Miyamoto</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomabechi, Daisuke" sort="Tomabechi, Daisuke" uniqKey="Tomabechi D" first="Daisuke" last="Tomabechi">Daisuke Tomabechi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kajihara, Masahiro" sort="Kajihara, Masahiro" uniqKey="Kajihara M" first="Masahiro" last="Kajihara">Masahiro Kajihara</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maruyama, Junki" sort="Maruyama, Junki" uniqKey="Maruyama J" first="Junki" last="Maruyama">Junki Maruyama</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kimura, Takashi" sort="Kimura, Takashi" uniqKey="Kimura T" first="Takashi" last="Kimura">Takashi Kimura</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manzoor, Rashid" sort="Manzoor, Rashid" uniqKey="Manzoor R" first="Rashid" last="Manzoor">Rashid Manzoor</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ito, Kimihito" sort="Ito, Kimihito" uniqKey="Ito K" first="Kimihito" last="Ito">Kimihito Ito</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Division of Bioinformatics, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Bioinformatics, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takada, Ayato" sort="Takada, Ayato" uniqKey="Takada A" first="Ayato" last="Takada">Ayato Takada</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Influenza A virus subtypes are classified on the basis of the antigenicity of their envelope glycoproteins, hemagglutinin (HA; H1–H17) and neuraminidase. Since HA-specific neutralizing antibodies are predominantly specific for a single HA subtype, the contribution of antibodies to the heterosubtypic immunity is not fully understood. In this study, mice were immunized intranasally or subcutaneously with viruses having the H1, H3, H5, H7, H9, or H13 HA subtype, and cross-reactivities of induced IgG and IgA antibodies to recombinant HAs of the H1–H16 subtypes were analyzed. We found that both subcutaneous and intranasal immunizations induced antibody responses to multiple HAs of different subtypes, whereas IgA was not detected remarkably in mice immunized subcutaneously. Using serum, nasal wash, and trachea-lung wash samples of H9 virus-immunized mice, neutralizing activities of cross-reactive antibodies were then evaluated by plaque-reduction assays. As expected, no heterosubtypic neutralizing activity was detected by a standard neutralization test in which viruses were mixed with antibodies prior to inoculation into cultured cells. Interestingly, however, a remarkable reduction of plaque formation and extracellular release of the H12 virus, which was bound by the H9-induced cross-reactive antibodies, was observed when infected cells were subsequently cultured with the samples containing HA-specific cross-reactive IgA. This heterosubtypic plaque reduction was interfered when the samples were pretreated with anti-mouse IgA polyclonal serum. These results suggest that the majority of HA-specific cross-reactive IgG and IgA antibodies produced by immunization do not block cellular entry of viruses, but cross-reactive IgA may have the potential to inhibit viral egress from infected cells and thus to play a role in heterosubtypic immunity against influenza A viruses.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name>
</author>
<author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name>
</author>
<author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rohm, C" uniqKey="Rohm C">C Rohm</name>
</author>
<author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name>
</author>
<author><name sortKey="Suss, J" uniqKey="Suss J">J Suss</name>
</author>
<author><name sortKey="Mackenzie, J" uniqKey="Mackenzie J">J Mackenzie</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Munster, V" uniqKey="Munster V">V Munster</name>
</author>
<author><name sortKey="Wallensten, A" uniqKey="Wallensten A">A Wallensten</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gerhard, W" uniqKey="Gerhard W">W Gerhard</name>
</author>
<author><name sortKey="Mozdzanowska, K" uniqKey="Mozdzanowska K">K Mozdzanowska</name>
</author>
<author><name sortKey="Furchner, M" uniqKey="Furchner M">M Furchner</name>
</author>
<author><name sortKey="Washko, G" uniqKey="Washko G">G Washko</name>
</author>
<author><name sortKey="Maiese, K" uniqKey="Maiese K">K Maiese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ada, Gl" uniqKey="Ada G">GL Ada</name>
</author>
<author><name sortKey="Jones, Pd" uniqKey="Jones P">PD Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nguyen, Hh" uniqKey="Nguyen H">HH Nguyen</name>
</author>
<author><name sortKey="Van Ginkel, Fw" uniqKey="Van Ginkel F">FW van Ginkel</name>
</author>
<author><name sortKey="Vu, Hl" uniqKey="Vu H">HL Vu</name>
</author>
<author><name sortKey="Mcghee, Jr" uniqKey="Mcghee J">JR McGhee</name>
</author>
<author><name sortKey="Mestecky, J" uniqKey="Mestecky J">J Mestecky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Townsend, Ar" uniqKey="Townsend A">AR Townsend</name>
</author>
<author><name sortKey="Mcmichael, Aj" uniqKey="Mcmichael A">AJ McMichael</name>
</author>
<author><name sortKey="Carter, Np" uniqKey="Carter N">NP Carter</name>
</author>
<author><name sortKey="Huddleston, Ja" uniqKey="Huddleston J">JA Huddleston</name>
</author>
<author><name sortKey="Brownlee, Gg" uniqKey="Brownlee G">GG Brownlee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name>
</author>
<author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name>
</author>
<author><name sortKey="Smith, Gl" uniqKey="Smith G">GL Smith</name>
</author>
<author><name sortKey="Moss, B" uniqKey="Moss B">B Moss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stropkovska, A" uniqKey="Stropkovska A">A Stropkovska</name>
</author>
<author><name sortKey="Mucha, V" uniqKey="Mucha V">V Mucha</name>
</author>
<author><name sortKey="Fislova, T" uniqKey="Fislova T">T Fislova</name>
</author>
<author><name sortKey="Gocnik, M" uniqKey="Gocnik M">M Gocnik</name>
</author>
<author><name sortKey="Kostolansky, F" uniqKey="Kostolansky F">F Kostolansky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sakabe, S" uniqKey="Sakabe S">S Sakabe</name>
</author>
<author><name sortKey="Iwatsuki Horimoto, K" uniqKey="Iwatsuki Horimoto K">K Iwatsuki-Horimoto</name>
</author>
<author><name sortKey="Horimoto, T" uniqKey="Horimoto T">T Horimoto</name>
</author>
<author><name sortKey="Nidom, Ca" uniqKey="Nidom C">CA Nidom</name>
</author>
<author><name sortKey="Le, Mq" uniqKey="Le M">MQ Le</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name>
</author>
<author><name sortKey="Isegawa, Y" uniqKey="Isegawa Y">Y Isegawa</name>
</author>
<author><name sortKey="Sasao, F" uniqKey="Sasao F">F Sasao</name>
</author>
<author><name sortKey="Ueda, S" uniqKey="Ueda S">S Ueda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Throsby, M" uniqKey="Throsby M">M Throsby</name>
</author>
<author><name sortKey="Van Den Brink, E" uniqKey="Van Den Brink E">E van den Brink</name>
</author>
<author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Alard, P" uniqKey="Alard P">P Alard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name>
</author>
<author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name>
</author>
<author><name sortKey="Elsliger, Ma" uniqKey="Elsliger M">MA Elsliger</name>
</author>
<author><name sortKey="Friesen, Rh" uniqKey="Friesen R">RH Friesen</name>
</author>
<author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name>
</author>
<author><name sortKey="Friesen, Rh" uniqKey="Friesen R">RH Friesen</name>
</author>
<author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name>
</author>
<author><name sortKey="Kwaks, T" uniqKey="Kwaks T">T Kwaks</name>
</author>
<author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohshima, N" uniqKey="Ohshima N">N Ohshima</name>
</author>
<author><name sortKey="Iba, Y" uniqKey="Iba Y">Y Iba</name>
</author>
<author><name sortKey="Kubota Koketsu, R" uniqKey="Kubota Koketsu R">R Kubota-Koketsu</name>
</author>
<author><name sortKey="Asano, Y" uniqKey="Asano Y">Y Asano</name>
</author>
<author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R Yoshida</name>
</author>
<author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M Igarashi</name>
</author>
<author><name sortKey="Ozaki, H" uniqKey="Ozaki H">H Ozaki</name>
</author>
<author><name sortKey="Kishida, N" uniqKey="Kishida N">N Kishida</name>
</author>
<author><name sortKey="Tomabechi, D" uniqKey="Tomabechi D">D Tomabechi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name>
</author>
<author><name sortKey="Suguitan, Al" uniqKey="Suguitan A">AL Suguitan</name>
</author>
<author><name sortKey="Pinna, D" uniqKey="Pinna D">D Pinna</name>
</author>
<author><name sortKey="Silacci, C" uniqKey="Silacci C">C Silacci</name>
</author>
<author><name sortKey="Fernandez Rodriguez, Bm" uniqKey="Fernandez Rodriguez B">BM Fernandez-Rodriguez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wrammert, J" uniqKey="Wrammert J">J Wrammert</name>
</author>
<author><name sortKey="Koutsonanos, D" uniqKey="Koutsonanos D">D Koutsonanos</name>
</author>
<author><name sortKey="Li, Gm" uniqKey="Li G">GM Li</name>
</author>
<author><name sortKey="Edupuganti, S" uniqKey="Edupuganti S">S Edupuganti</name>
</author>
<author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Renshaw, M" uniqKey="Renshaw M">M Renshaw</name>
</author>
<author><name sortKey="Clements, Jd" uniqKey="Clements J">JD Clements</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takada, A" uniqKey="Takada A">A Takada</name>
</author>
<author><name sortKey="Matsushita, S" uniqKey="Matsushita S">S Matsushita</name>
</author>
<author><name sortKey="Ninomiya, A" uniqKey="Ninomiya A">A Ninomiya</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takada, A" uniqKey="Takada A">A Takada</name>
</author>
<author><name sortKey="Shimizu, Y" uniqKey="Shimizu Y">Y Shimizu</name>
</author>
<author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Stech, J" uniqKey="Stech J">J Stech</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakayama, E" uniqKey="Nakayama E">E Nakayama</name>
</author>
<author><name sortKey="Yokoyama, A" uniqKey="Yokoyama A">A Yokoyama</name>
</author>
<author><name sortKey="Miyamoto, H" uniqKey="Miyamoto H">H Miyamoto</name>
</author>
<author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M Igarashi</name>
</author>
<author><name sortKey="Kishida, N" uniqKey="Kishida N">N Kishida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aymard Henry, M" uniqKey="Aymard Henry M">M Aymard-Henry</name>
</author>
<author><name sortKey="Coleman, Mt" uniqKey="Coleman M">MT Coleman</name>
</author>
<author><name sortKey="Dowdle, Wr" uniqKey="Dowdle W">WR Dowdle</name>
</author>
<author><name sortKey="Laver, Wg" uniqKey="Laver W">WG Laver</name>
</author>
<author><name sortKey="Schild, Gc" uniqKey="Schild G">GC Schild</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renegar, Kb" uniqKey="Renegar K">KB Renegar</name>
</author>
<author><name sortKey="Small, Pa" uniqKey="Small P">PA Small</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manley, K" uniqKey="Manley K">K Manley</name>
</author>
<author><name sortKey="Anderson, J" uniqKey="Anderson J">J Anderson</name>
</author>
<author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name>
</author>
<author><name sortKey="Szustakowski, J" uniqKey="Szustakowski J">J Szustakowski</name>
</author>
<author><name sortKey="Oakeley, Ej" uniqKey="Oakeley E">EJ Oakeley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
<author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name>
</author>
<author><name sortKey="Peterson, N" uniqKey="Peterson N">N Peterson</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name>
</author>
<author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name>
</author>
<author><name sortKey="Haire, Lf" uniqKey="Haire L">LF Haire</name>
</author>
<author><name sortKey="Stevens, Dj" uniqKey="Stevens D">DJ Stevens</name>
</author>
<author><name sortKey="Xiao, B" uniqKey="Xiao B">B Xiao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name>
</author>
<author><name sortKey="Hwang, Wc" uniqKey="Hwang W">WC Hwang</name>
</author>
<author><name sortKey="Perez, S" uniqKey="Perez S">S Perez</name>
</author>
<author><name sortKey="Wei, G" uniqKey="Wei G">G Wei</name>
</author>
<author><name sortKey="Aird, D" uniqKey="Aird D">D Aird</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muto, Na" uniqKey="Muto N">NA Muto</name>
</author>
<author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R Yoshida</name>
</author>
<author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name>
</author>
<author><name sortKey="Kobayashi, S" uniqKey="Kobayashi S">S Kobayashi</name>
</author>
<author><name sortKey="Ozaki, H" uniqKey="Ozaki H">H Ozaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kajihara, M" uniqKey="Kajihara M">M Kajihara</name>
</author>
<author><name sortKey="Marzi, A" uniqKey="Marzi A">A Marzi</name>
</author>
<author><name sortKey="Nakayama, E" uniqKey="Nakayama E">E Nakayama</name>
</author>
<author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name>
</author>
<author><name sortKey="Kuroda, M" uniqKey="Kuroda M">M Kuroda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takada, A" uniqKey="Takada A">A Takada</name>
</author>
<author><name sortKey="Kuboki, N" uniqKey="Kuboki N">N Kuboki</name>
</author>
<author><name sortKey="Okazaki, K" uniqKey="Okazaki K">K Okazaki</name>
</author>
<author><name sortKey="Ninomiya, A" uniqKey="Ninomiya A">A Ninomiya</name>
</author>
<author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ichinohe, T" uniqKey="Ichinohe T">T Ichinohe</name>
</author>
<author><name sortKey="Tamura, S" uniqKey="Tamura S">S Tamura</name>
</author>
<author><name sortKey="Kawaguchi, A" uniqKey="Kawaguchi A">A Kawaguchi</name>
</author>
<author><name sortKey="Ninomiya, A" uniqKey="Ninomiya A">A Ninomiya</name>
</author>
<author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name>
</author>
<author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name>
</author>
<author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author><name sortKey="Pica, N" uniqKey="Pica N">N Pica</name>
</author>
<author><name sortKey="Petersen, E" uniqKey="Petersen E">E Petersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamm, Me" uniqKey="Lamm M">ME Lamm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
<author><name sortKey="Joseph, T" uniqKey="Joseph T">T Joseph</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zebedee, Sl" uniqKey="Zebedee S">SL Zebedee</name>
</author>
<author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Reay, Pa" uniqKey="Reay P">PA Reay</name>
</author>
<author><name sortKey="Laver, Wg" uniqKey="Laver W">WG Laver</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughey, Pg" uniqKey="Hughey P">PG Hughey</name>
</author>
<author><name sortKey="Roberts, Pc" uniqKey="Roberts P">PC Roberts</name>
</author>
<author><name sortKey="Holsinger, Lj" uniqKey="Holsinger L">LJ Holsinger</name>
</author>
<author><name sortKey="Zebedee, Sl" uniqKey="Zebedee S">SL Zebedee</name>
</author>
<author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name>
</author>
<author><name sortKey="Tierney, El" uniqKey="Tierney E">EL Tierney</name>
</author>
<author><name sortKey="Zebedee, Sl" uniqKey="Zebedee S">SL Zebedee</name>
</author>
<author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name>
</author>
<author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mazanec, Mb" uniqKey="Mazanec M">MB Mazanec</name>
</author>
<author><name sortKey="Coudret, Cl" uniqKey="Coudret C">CL Coudret</name>
</author>
<author><name sortKey="Fletcher, Dr" uniqKey="Fletcher D">DR Fletcher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wright, A" uniqKey="Wright A">A Wright</name>
</author>
<author><name sortKey="Yan, H" uniqKey="Yan H">H Yan</name>
</author>
<author><name sortKey="Lamm, Me" uniqKey="Lamm M">ME Lamm</name>
</author>
<author><name sortKey="Huang, Yt" uniqKey="Huang Y">YT Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, D" uniqKey="Zhou D">D Zhou</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="He, B" uniqKey="He B">B He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corthesy, B" uniqKey="Corthesy B">B Corthesy</name>
</author>
<author><name sortKey="Benureau, Y" uniqKey="Benureau Y">Y Benureau</name>
</author>
<author><name sortKey="Perrier, C" uniqKey="Perrier C">C Perrier</name>
</author>
<author><name sortKey="Fourgeux, C" uniqKey="Fourgeux C">C Fourgeux</name>
</author>
<author><name sortKey="Parez, N" uniqKey="Parez N">N Parez</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Muramatsu, Mieko" sort="Muramatsu, Mieko" uniqKey="Muramatsu M" first="Mieko" last="Muramatsu">Mieko Muramatsu</name>
</noRegion>
<name sortKey="Ito, Kimihito" sort="Ito, Kimihito" uniqKey="Ito K" first="Kimihito" last="Ito">Kimihito Ito</name>
<name sortKey="Kajihara, Masahiro" sort="Kajihara, Masahiro" uniqKey="Kajihara M" first="Masahiro" last="Kajihara">Masahiro Kajihara</name>
<name sortKey="Kimura, Takashi" sort="Kimura, Takashi" uniqKey="Kimura T" first="Takashi" last="Kimura">Takashi Kimura</name>
<name sortKey="Manzoor, Rashid" sort="Manzoor, Rashid" uniqKey="Manzoor R" first="Rashid" last="Manzoor">Rashid Manzoor</name>
<name sortKey="Maruyama, Junki" sort="Maruyama, Junki" uniqKey="Maruyama J" first="Junki" last="Maruyama">Junki Maruyama</name>
<name sortKey="Miyamoto, Hiroko" sort="Miyamoto, Hiroko" uniqKey="Miyamoto H" first="Hiroko" last="Miyamoto">Hiroko Miyamoto</name>
<name sortKey="Takada, Ayato" sort="Takada, Ayato" uniqKey="Takada A" first="Ayato" last="Takada">Ayato Takada</name>
<name sortKey="Tomabechi, Daisuke" sort="Tomabechi, Daisuke" uniqKey="Tomabechi D" first="Daisuke" last="Tomabechi">Daisuke Tomabechi</name>
<name sortKey="Yoshida, Reiko" sort="Yoshida, Reiko" uniqKey="Yoshida R" first="Reiko" last="Yoshida">Reiko Yoshida</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000886 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000886 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3745432 |texte= Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23977065" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |